Endothelial nitric oxide synthase gene G894T polymorphism and myocardial infarction: a meta-analysis of 34 studies involving 21,068 subjects

PLoS One. 2014 Jan 30;9(1):e87196. doi: 10.1371/journal.pone.0087196. eCollection 2014.

Abstract

Background: Researches have revealed that the endothelial nitric oxide synthase (eNOS) gene G894T polymorphism is associated with the risk of Myocardial infarction (MI), but the results remain conflicting.

Objective and methods: A meta-analysis was conducted to investigate the association between eNOS G894T polymorphism and MI. Published studies from PubMed, Embase, CNKI and CBM databases were retrieved. The pooled odds ratios (ORs) for the association between eNOS G894T polymorphism and MI and their corresponding 95% confidence intervals (CIs) were estimated using the random- or fixed- effect model.

Results: A total of 34 studies including 8229 cases and 12839 controls were identified for the meta-analysis. The eNOS G894T polymorphism was significantly associated with MI under a homozygous genetic model (OR = 1.41, 95% CI = 1.08-1.84; P = 0.012), a recessive genetic model (OR = 1.35, 95% CI = 1.06-1.70; P = 0.014), a dominant genetic model (OR = 1.18, 95% CI = 1.04-1.34; P = 0.009). In the subgroup analysis by ethnicity (non-Asian and Asian), no significant association was observed between eNOS G894T polymorphism and MI risk among non-Asians (P>0.05), but a positive significant association was found among Asians (P<0.05).

Conclusions: The eNOS G894T polymorphism is associated with increased MI risk in Asians. The results indicate that ethnicity plays important roles in the association between eNOS G894T polymorphism and MI.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Asian People / genetics
  • Case-Control Studies
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Myocardial Infarction / etiology
  • Myocardial Infarction / genetics*
  • Nitric Oxide Synthase Type III / genetics*
  • Polymorphism, Genetic / genetics*
  • Risk

Substances

  • NOS3 protein, human
  • Nitric Oxide Synthase Type III

Grants and funding

The work was supported by the National Scientific Foundation of China (No. 81273595, 81202594, 81001445), the “863” Project (No. 2012AA02A518), the Scientific Foundation of Hunan (No. 11K073, 10JJ4020). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.