Abstract
Humanized mouse models have been developed and utilized in cancer research for decades. Newly developed combined immunodeficient NOD-SCID-IL2rg–/– mice are more permissive for human cells and tissue engraftment. In this review, we discuss the use of NOD-SCID-IL2rg(–/–) mice as a preclinical tool in cancer research and its potential use for individualized cancer therapies.
MeSH terms
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Animals
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Disease Models, Animal*
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Humans
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Interleukin Receptor Common gamma Subunit / deficiency
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Interleukin Receptor Common gamma Subunit / genetics
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Mice
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Mice, Inbred NOD
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Mice, Knockout
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Mice, SCID
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Mice, Transgenic
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Neoplasms*
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Precision Medicine / methods*
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Precision Medicine / trends
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Xenograft Model Antitumor Assays / methods*
Substances
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Il2rg protein, mouse
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Interleukin Receptor Common gamma Subunit