Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration

Hyung Jin Choi; Dong-Hwa Lee; Hyun Jeong Jeon; Dae Soon Kim; Yong Hee Lee; Taekeun Oh

doi:10.1016/j.diabres.2013.12.051

Transcription factor 7-like 2 (TCF7L2) gene polymorphism rs7903146 is associated with stroke in type 2 diabetes patients with long disease duration

Diabetes Res Clin Pract. 2014 Mar;103(3):e3-6. doi: 10.1016/j.diabres.2013.12.051. Epub 2014 Jan 15.

Authors

Hyung Jin Choi¹, Dong-Hwa Lee¹, Hyun Jeong Jeon¹, Dae Soon Kim², Yong Hee Lee², Taekeun Oh³

Affiliations

¹ Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.
² Department of Biochemistry, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea.
³ Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju Si, Republic of Korea. Electronic address: tgohkjs@chungbuk.ac.kr.

PMID: 24529562
DOI: 10.1016/j.diabres.2013.12.051

Abstract

Associations between TCF7L2 SNP and diabetic complications and diabetes-related factors were investigated. Subjects with rs7903146 variant had significantly higher prevalence of stroke (24.1% vs. 11.1%; P=0.039) among subjects exhibiting a long disease duration (≥10 years). In conclusion, the TCF7L2 SNP variant may confer a higher risk of stroke in diabetic patients.

Keywords: Complication; SNP; TCF7L2.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Diabetes Mellitus, Type 2 / epidemiology
Diabetes Mellitus, Type 2 / genetics*
Female
Genetic Predisposition to Disease
Genotype
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Prevalence
Prognosis
Risk Factors
Stroke / epidemiology
Stroke / genetics*
Time Factors
Transcription Factor 7-Like 2 Protein / genetics*

Substances

TCF7L2 protein, human
Transcription Factor 7-Like 2 Protein