Abstract
CD1 molecules bind and present lipid-based antigens to T cells. Humans express both Group 1 (CD1a, CD1b and CD1c) and Group 2 (CD1d) CD1 molecules with nonredundant functions in the human immune response. Studies of Group 1 CD1 molecules and the T cells that respond to them have lagged behind Group 2 due to the lack of a suitable model system. However, recent work has thrust the Group 1 CD1s into the limelight, revealing their importance in tissue surveillance and microbial defense. Here I review recent advances in Group 1 CD1 lipid presentation, the T cell populations that respond to them and the role of CD1 molecules in engagement of human γδ T cells.
Copyright © 2013 Elsevier Ltd. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Antigen Presentation / genetics
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Antigen Presentation / immunology*
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Antigens, CD1 / genetics
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Antigens, CD1 / immunology
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Antigens, CD1 / metabolism*
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Antigens, CD1d / genetics
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Antigens, CD1d / immunology
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Antigens, CD1d / metabolism
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Gene Expression Regulation / immunology
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Glycoproteins / genetics
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Glycoproteins / immunology
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Glycoproteins / metabolism
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Humans
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Lipid Mobilization / genetics
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Lipid Mobilization / immunology*
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Protein Binding / genetics
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Protein Binding / immunology
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T-Lymphocyte Subsets / classification
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T-Lymphocyte Subsets / immunology*
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T-Lymphocyte Subsets / metabolism*
Substances
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Antigens, CD1
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Antigens, CD1d
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CD1C protein, human
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CD1D protein, human
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CD1a antigen
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CD1b antigen
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Glycoproteins