No association of four candidate genetic variants in MnSOD and SYNIII with Parkinson's disease in two Chinese populations

PLoS One. 2014 Feb 26;9(2):e88050. doi: 10.1371/journal.pone.0088050. eCollection 2014.

Abstract

Background: The manganese superoxide dismutase (MnSOD) gene, which encodes a chief reactive oxygen species (ROS) scavenging enzyme, has been reported to be associated with the risk of developing sporadic Parkinson's disease (PD) in some Asian races and the synapsin III (SYN3) gene with some neuropsychiatric diseases.

Objective: To explore the associations between the MnSOD and SYN III variations and PD in two Chinese populations from mainland China and Singapore.

Methods: We recruited 2342 subjects including 1200 sporadic PD patients and 1142 healthy controls from two independent Asian countries. Using a case-control methodology, we genotyped the single nucleotide polymorphisms (SNP) in MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) to explore the associations with risk of PD.

Results: The results showed the genotype distributions and minor allele frequencies (MAF) of MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) were not significantly different between PD patients and healthy controls in mainland China and Singapore, as well as in merged populations.

Conclusions: The variations of MnSOD (rs4880) and SYN III (rs3788470, rs3827336, rs5998557) were not major risk factors for PD among Chinese, at least in our study populations.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • China
  • Female
  • Genetic Variation*
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / genetics*
  • Superoxide Dismutase / genetics*
  • Synucleins / genetics*

Substances

  • Synucleins
  • Superoxide Dismutase

Grants and funding

This work was supported by the Science and Technology Support Program, Science and Technology Department of Sichuan province. The grant numbers are 2013SZ0003. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.