Meta-analysis of the rs4779584 polymorphism and colorectal cancer risk

PLoS One. 2014 Feb 24;9(2):e89736. doi: 10.1371/journal.pone.0089736. eCollection 2014.

Abstract

Purpose: Several researchers have suggested that the rs4779584 (15q13.3) polymorphism is associated with an increased risk of developing colorectal cancer (CRC). However, past results remain inconclusive. We addressed this controversy by performing a meta-analysis of the relationship between rs4779584 of GREM1-SCG5 and colorectal cancer.

Methods: We selected 12 case-control studies involving 11,769 cases of CRC and 14,328 healthy controls. The association between the rs4779584 polymorphism and CRC was examined by the overall odds ratio (OR) with a 95% confidence interval (CI). We used different genetic model analyses, sensitivity analyses, and assessments of bias in our meta-analysis.

Results: GREM1-SCG5 rs4779584 polymorphisms were associated with CRC in all of the genetic models that were examined in this meta-analysis of 12 case-control studies.

Conclusion: GREM1-SCG5 rs4779584 polymorphisms may increase the risk of developing colorectal cancer.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human, Pair 15 / genetics*
  • Colorectal Neoplasms / genetics*
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Intercellular Signaling Peptides and Proteins / genetics
  • Models, Genetic
  • Neuroendocrine Secretory Protein 7B2 / genetics
  • Odds Ratio
  • Polymorphism, Single Nucleotide / genetics*
  • Regression Analysis

Substances

  • GREM1 protein, human
  • Intercellular Signaling Peptides and Proteins
  • Neuroendocrine Secretory Protein 7B2
  • SCG5 protein, human

Grants and funding

This work was supported by the National 863 High-Technology Research and Development Program (No. 2012AA02A519). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.