Abstract
IWS1 phosphorylation by AKT1 and AKT3 shifts splicing towards a tumorigenic FGFR2 isoform.
MeSH terms
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Alternative Splicing
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Gene Expression Regulation, Neoplastic
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Humans
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Lung Neoplasms / genetics
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Lung Neoplasms / pathology*
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Phosphorylation
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Protein Isoforms / genetics
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Protein Isoforms / metabolism
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Proto-Oncogene Proteins c-akt / metabolism*
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Receptor, Fibroblast Growth Factor, Type 2 / genetics*
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Receptor, Fibroblast Growth Factor, Type 2 / metabolism
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Signal Transduction
Substances
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Protein Isoforms
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Receptor, Fibroblast Growth Factor, Type 2
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Proto-Oncogene Proteins c-akt