AKT isoform-specific signals regulate RNA processing in lung cancer

Cancer Discov. 2014 Mar;4(3):OF17. doi: 10.1158/2159-8290.CD-RW2014-028. Epub 2014 Feb 6.

Abstract

IWS1 phosphorylation by AKT1 and AKT3 shifts splicing towards a tumorigenic FGFR2 isoform.

Publication types

  • News

MeSH terms

  • Alternative Splicing
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Lung Neoplasms / genetics
  • Lung Neoplasms / pathology*
  • Phosphorylation
  • Protein Isoforms / genetics
  • Protein Isoforms / metabolism
  • Proto-Oncogene Proteins c-akt / metabolism*
  • Receptor, Fibroblast Growth Factor, Type 2 / genetics*
  • Receptor, Fibroblast Growth Factor, Type 2 / metabolism
  • Signal Transduction

Substances

  • Protein Isoforms
  • Receptor, Fibroblast Growth Factor, Type 2
  • Proto-Oncogene Proteins c-akt