Is the interleukin 8 promoter polymorphism rs4073/-251T >A associated with Clostridium difficile infection?

Clin Infect Dis. 2014 Jun;58(12):e148-51. doi: 10.1093/cid/ciu152. Epub 2014 Mar 14.

Abstract

The interleukin 8 gene single-nucleotide polymorphism rs4073/-251T >A predisposes to Clostridium difficile infection (CDI), but this association has not been independently validated. In this study, we were unable to replicate this association in either a white cohort or by meta-analysis, suggesting that rs4073/-251T >A is unlikely to constitute a major risk factor for CDI.

Keywords: Clostridium difficile; genetic predisposition; host response; interleukin 8; meta-analysis.

Publication types

  • Meta-Analysis
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Anti-Bacterial Agents / adverse effects
  • Case-Control Studies
  • Clostridioides difficile
  • Diarrhea / chemically induced
  • Diarrhea / genetics
  • Enterocolitis, Pseudomembranous / genetics*
  • Feces / chemistry
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Interleukin-8 / analysis
  • Interleukin-8 / genetics*
  • Male
  • Polymorphism, Single Nucleotide
  • Promoter Regions, Genetic / genetics*

Substances

  • Anti-Bacterial Agents
  • Interleukin-8