The emerging role of MMP14 in brain tumorigenesis and future therapeutics

Biochim Biophys Acta. 2014 Aug;1846(1):113-20. doi: 10.1016/j.bbcan.2014.03.002. Epub 2014 Mar 19.

Abstract

Glioblastoma is a malignant brain tumor of glial origin. These tumors are thought to be derived from astrocytic cells that undergo malignant transformation. A growing body of evidence suggests that upregulation of MMP expression plays a significant role in promoting glioma pathogenesis. Elevated expression of MMP14 not only promotes glioma invasion and tumor cell proliferation but also plays a role in angiogenesis. Despite the fact that levels of MMP14 correlate with breast cancer progression, the controversial role of MMP14 in gliomagenesis needs to be elucidated. In the present review, we discuss the role of MMP14 in glioma progression as well as the mechanisms of MMP14 regulation in the context of future therapeutic manipulations.

Keywords: Angiogenesis; Brain; Glioblastoma; Invasion; MMP14; Tumor.

Publication types

  • Review

MeSH terms

  • Animals
  • Brain / pathology
  • Brain Neoplasms / genetics
  • Brain Neoplasms / pathology*
  • Brain Neoplasms / therapy*
  • Carcinogenesis / genetics*
  • Carcinogenesis / metabolism
  • Glioblastoma / genetics
  • Glioblastoma / pathology*
  • Glioblastoma / therapy*
  • Humans
  • Matrix Metalloproteinase 14 / genetics
  • Matrix Metalloproteinase 14 / physiology*
  • Molecular Targeted Therapy
  • Xenograft Model Antitumor Assays

Substances

  • MMP14 protein, human
  • Matrix Metalloproteinase 14