Cyclin D1 transcriptional activation in MCL

Blood. 2014 Mar 27;123(13):1979-80. doi: 10.1182/blood-2014-02-553057.

Abstract

In this issue of Blood, Allinne et al propose the nucleolin-dependent activation of the translocated CCND1 allele in mantle cell lymphoma (MCL) because of its relocalization to a transcriptionally favorable area in the perinucleolar region.

Publication types

  • Comment

MeSH terms

  • Cell Nucleolus / metabolism*
  • Cyclin D1 / metabolism*
  • Gene Expression Regulation, Neoplastic*
  • Humans
  • Lymphoma, Mantle-Cell / genetics*
  • Nucleolin
  • Phosphoproteins / metabolism*
  • RNA-Binding Proteins / metabolism*
  • Transcriptional Activation*

Substances

  • Phosphoproteins
  • RNA-Binding Proteins
  • Cyclin D1