Muscle matters in Kennedy's disease

Carlo Rinaldi; Laura C Bott; Kenneth H Fischbeck

doi:10.1016/j.neuron.2014.04.005

Muscle matters in Kennedy's disease

Neuron. 2014 Apr 16;82(2):251-3. doi: 10.1016/j.neuron.2014.04.005.

Authors

Carlo Rinaldi¹, Laura C Bott², Kenneth H Fischbeck³

Affiliations

¹ Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA.
² Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA; Department of Cell and Molecular Biology, Karolinska Institute, 17177 Stockholm, Sweden.
³ Neurogenetics Branch, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: kf@ninds.nih.gov.

Abstract

Polyglutamine expansion in the androgen receptor causes Kennedy's disease. Two recent reports, Cortes et al. (2014) in this issue of Neuron and Lieberman et al. (2014) in Cell Reports, raise the possibility that targeting expression of the mutant protein in skeletal muscle, instead of the nervous system, may mitigate manifestations of this disorder.

Publication types

Comment

MeSH terms

Animals
Brain / pathology*
Humans
Male
Muscle, Skeletal / metabolism*
Muscular Disorders, Atrophic / genetics*
Muscular Disorders, Atrophic / pathology*
Peptides / genetics*
Receptors, Androgen / genetics*

Substances

Peptides
Receptors, Androgen
polyglutamine

Grants and funding

ZIA NS003038-07/Intramural NIH HHS/United States