A single nucleotide polymorphism in SLC1A1 gene is associated with age of onset of obsessive-compulsive disorder

S Dallaspezia; M Mazza; C Lorenzi; F Benedetti; E Smeraldi

doi:10.1016/j.eurpsy.2014.02.006

A single nucleotide polymorphism in SLC1A1 gene is associated with age of onset of obsessive-compulsive disorder

Eur Psychiatry. 2014 Jun;29(5):301-3. doi: 10.1016/j.eurpsy.2014.02.006. Epub 2014 Apr 24.

Authors

S Dallaspezia¹, M Mazza², C Lorenzi², F Benedetti², E Smeraldi²

Affiliations

¹ Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy. Electronic address: dallaspezia.sara@hsr.it.
² Department of Clinical Neurosciences, Scientific Institute and University Vita-Salute San Raffaele, Milan, Italy.

PMID: 24768158
DOI: 10.1016/j.eurpsy.2014.02.006

Abstract

Different genetic polymorphisms in the SLC1A1 have been shown to be associated with obsessive-compulsive disorder. Rs301430 is a T/C functional polymorphism affecting the gene expression and extrasynaptic glutamate concentration.We observed that Rs301430 influence age at onset in obsessive-compulsive disorder.

Keywords: Age at onset; Glutamate; Obsessive-compulsive disorder; Rs301430; SLC1A1.

MeSH terms

Adolescent
Adult
Age of Onset
Child
Excitatory Amino Acid Transporter 3 / genetics*
Female
Genetic Predisposition to Disease
Genotype
Haplotypes
Humans
Male
Obsessive-Compulsive Disorder / diagnosis*
Obsessive-Compulsive Disorder / genetics*
Polymorphism, Single Nucleotide*
Young Adult

Substances

Excitatory Amino Acid Transporter 3
SLC1A1 protein, human