BRAF inhibitor resistance can be overcome by blocking autophagy

Cancer Discov. 2014 May;4(5):OF10. doi: 10.1158/2159-8290.CD-RW2014-059. Epub 2014 Mar 13.

Abstract

ER stress-induced autophagy confers resistance to BRAF inhibitors in BRAF-mutant melanoma.

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology
  • Autophagy / drug effects*
  • Drug Resistance, Neoplasm*
  • Heterografts
  • Humans
  • Melanoma
  • Mice
  • Proto-Oncogene Proteins B-raf / antagonists & inhibitors*
  • Proto-Oncogene Proteins B-raf / genetics
  • Proto-Oncogene Proteins B-raf / metabolism

Substances

  • Antineoplastic Agents
  • BRAF protein, human
  • Proto-Oncogene Proteins B-raf