Angiogenesis-related gene mutations drive a subset of angiosarcomas

Cancer Discov. 2014 May;4(5):OF18. doi: 10.1158/2159-8290.CD-RW2014-069. Epub 2014 Mar 27.

Abstract

Recurrent mutations in PTPRB and PLCG1 were identified in angiosarcomas.

MeSH terms

  • Genome, Human
  • Hemangiosarcoma / genetics*
  • Hemangiosarcoma / pathology
  • Humans
  • Mutation
  • Phospholipase C gamma / genetics*
  • Receptor-Like Protein Tyrosine Phosphatases, Class 3 / genetics*
  • Sequence Analysis, DNA

Substances

  • PTPRB protein, human
  • Receptor-Like Protein Tyrosine Phosphatases, Class 3
  • PLCG1 protein, human
  • Phospholipase C gamma