Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report

Stephanie L Holdener; Lacey Harrington; Johnny Nguyen; Pedro Horna; Elizabeth Sagatys; Bijal Shah; Ling Zhang

Therapy-related B lymphoblastic leukemia with t(4;11)(q21;q23)/AF4-MLL in a patient with mantle cell lymphoma after recent aggressive chemotherapy: a unique case report

Int J Clin Exp Pathol. 2014 Mar 15;7(4):1800-4. eCollection 2014.

Authors

Stephanie L Holdener¹, Lacey Harrington¹, Johnny Nguyen¹, Pedro Horna², Elizabeth Sagatys², Bijal Shah³, Ling Zhang²

Affiliations

¹ Department of Pathology, University of South Florida Morsani College of Medicine Tampa, FL, USA.
² Department of Hematopathology and Laboratory Medicine, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.
³ Department of Hematological Malignancies, H. Lee Moffitt Cancer Center and Research Institute Tampa, FL, USA.

PMID: 24817983
PMCID: PMC4014267

Abstract

Mantle cell lymphoma (MCL) is a mature B-cell lymphoma associated with the hallmark translocation t(11;14)(q13;32), which involves the cyclin D1 (CCND1) and immunoglobin heavy chain (IgH) genes. It may transform to a more aggressive blastoid or pleomorphic variant, with or without acquisition of chromosomal abnormalities. MCL could also present with a leukemic phase with marked lymphocytosis. A literature search did not reveal any prior reports of MCL transforming to or followed by a B-cell lymphoblastic leukemia (B-ALL).

Keywords: Mantle; lymphoma; therapy; transformation; variant.

Publication types

Case Reports
Review

MeSH terms

Chromosomes, Human, Pair 11 / genetics*
Chromosomes, Human, Pair 4 / genetics*
Cyclin D1 / genetics
DNA-Binding Proteins / genetics*
Drug Therapy
Drug-Related Side Effects and Adverse Reactions / complications
Gene Rearrangement
Histone-Lysine N-Methyltransferase
Humans
Immunoglobulin Heavy Chains / genetics
Lymphoma, Mantle-Cell / drug therapy*
Male
Middle Aged
Myeloid-Lymphoid Leukemia Protein / genetics*
Nuclear Proteins / genetics*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology*
Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
Transcriptional Elongation Factors
Translocation, Genetic / genetics*
Treatment Outcome

Substances

DNA-Binding Proteins
Immunoglobulin Heavy Chains
KMT2A protein, human
Nuclear Proteins
Transcriptional Elongation Factors
Cyclin D1
Myeloid-Lymphoid Leukemia Protein
AFF1 protein, human
Histone-Lysine N-Methyltransferase