IL-10 and macrophages orchestrate gut homeostasis

Alberto Mantovani; Federica Marchesi

doi:10.1016/j.immuni.2014.04.015

IL-10 and macrophages orchestrate gut homeostasis

Immunity. 2014 May 15;40(5):637-9. doi: 10.1016/j.immuni.2014.04.015.

Authors

Alberto Mantovani¹, Federica Marchesi²

Affiliations

¹ Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy. Electronic address: alberto.mantovani@humanitasresearch.it.
² Humanitas Clinical and Research Center, Via Manzoni 56, 20089 Rozzano, Italy, and Department of Biotechnologies and Translational Medicine, University of Milan, 20122 Milan, Italy.

PMID: 24837099
DOI: 10.1016/j.immuni.2014.04.015

Abstract

Macrophages in the gut originate from blood precursors and have distinct functional properties. In this issue of Immunity,Zigmond et al. (2014) and Shouval et al. (2014) report that interleukin-10 drives macrophages to express homeostatic tolerogenic functions, preventing colitis.

Publication types

Comment

MeSH terms

Animals
Colitis, Ulcerative / genetics*
Colitis, Ulcerative / immunology*
Humans
Interleukin-10 / immunology*
Macrophages / immunology*
Receptors, Interleukin-10 / immunology*

Substances

IL10 protein, mouse
Receptors, Interleukin-10
Interleukin-10