Abstract
Breast cancer is the most common in women worldwide, with some 5-10% of all cases due to inherited mutations of BRCA1 and BRCA2 genes. Obesity, hormone therapy and use of alcohol are possible causes and over-expression of leptin in adipose tissue may also play a role. Normally surgery, radiation therapy and chemotherapy allow a good prognosis where screening measures are in place. New hope in treatment measures include adjuvant therapy, neoadjuvant therapy, and introduction of mono-clonal antibodies and enzyme inhibitors.
MeSH terms
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Adipose Tissue / metabolism
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Alcohol Drinking / epidemiology
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Breast Neoplasms / epidemiology*
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Breast Neoplasms / genetics
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Breast Neoplasms / therapy
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Carcinoma, Ductal, Breast / epidemiology*
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Carcinoma, Ductal, Breast / genetics
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Carcinoma, Ductal, Breast / therapy
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Carcinoma, Lobular / epidemiology*
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Carcinoma, Lobular / genetics
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Carcinoma, Lobular / therapy
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Chemotherapy, Adjuvant
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Estrogen Replacement Therapy / statistics & numerical data
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Female
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Genes, BRCA1
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Genes, BRCA2
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Humans
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Leptin / metabolism
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Mastectomy
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Neoadjuvant Therapy
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Obesity / epidemiology
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Obesity / metabolism
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Radiotherapy, Adjuvant
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Risk Factors
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Sedentary Behavior
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Selective Estrogen Receptor Modulators / therapeutic use
Substances
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Leptin
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Selective Estrogen Receptor Modulators