Relationship of the FKBP5 C/T polymorphism with dysfunctional attitudes predisposing to depression

Compr Psychiatry. 2014 Aug;55(6):1422-5. doi: 10.1016/j.comppsych.2014.04.019. Epub 2014 May 4.

Abstract

FK506-binding protein 51 (FKBP5) is a co-chaperone of the glucocorticoid receptor, and plays an important role in the negative feedback regulation of the hypothalamic-pituitary-adrenal axis. The C/T single nucleotide polymorphism in the intron 2 of the FKBP5 gene affects cortisol secretion, and has been implicated in the pathophysiology of depression. In this study, the relationship of the FKBP5 C/T polymorphism with dysfunctional attitudes predisposing to depression was examined. The subjects were 300 healthy Japanese. The FKBP5 genotypes were determined by a real-time PCR and cycling probe technology for SNP typing. Dysfunctional attitudes were assessed by the 24-item version of the Dysfunctional Attitude Scale (DAS-24), which has the Achievement, Self-control, and Dependency subscales. DAS-24 total scores were significantly higher in the group with the T allele than in that without this allele (p=0.001). Regarding the subscales, scores of the Achievement (p=0.003) and Self-control (p=0.009) subscales, but not those of the Dependency subscale, were significantly higher in the former group than in the latter group. The present study suggests that the FKBP5 C/T polymorphism is implicated in formation of dysfunctional attitudes, especially those about achievement and self-control.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Achievement*
  • Adult
  • Asian People / genetics
  • Asian People / psychology
  • Asian People / statistics & numerical data
  • Attitude*
  • Cytosine
  • Dependency, Psychological
  • Depression / genetics*
  • Depression / psychology*
  • Female
  • Gene Frequency
  • Humans
  • Hypothalamo-Hypophyseal System / metabolism
  • Internal-External Control*
  • Japan
  • Male
  • Middle Aged
  • Pituitary-Adrenal System / metabolism
  • Polymorphism, Single Nucleotide*
  • Real-Time Polymerase Chain Reaction
  • Risk Factors
  • Tacrolimus Binding Proteins / genetics*
  • Tacrolimus Binding Proteins / metabolism
  • Thymine

Substances

  • Cytosine
  • Tacrolimus Binding Proteins
  • tacrolimus binding protein 5
  • Thymine