Abstract
For patients with advanced non-small cell lung adenocarcinoma that fail to respond to first-line chemotherapy and that do not involve epidermal growth factor receptor (EGFR) mutations, previous empirical analysis showed that a single second-line chemotherapy agent may be inadequate for the control of further tumor development. This study examines the combination of S-1 drugs and nedaplatin that has no cross-resistance to first-line treatments; 179 cases of IIIb-IV stage non-small-cell lung adenocarcinoma that failed to respond to first-line chemotherapy were included, and these subjects did not have mutated EGFRs. In the present study, S-1 plus nedaplatin chemotherapy was better than standard second-line chemotherapy options in the treatment of advanced lung adenocarcinoma that did not involve EGFR mutations and that failed to respond to first-line chemotherapy. Additionally, the combination of S-1 and nedaplatin seemed to be well tolerated, making this chemotherapy technique a potentially strong candidate for the treatment of advanced non-small-cell lung adenocarcinoma.
MeSH terms
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Adenocarcinoma / drug therapy*
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Adenocarcinoma / genetics
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Adenocarcinoma / pathology
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Adult
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Aged
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Anemia / chemically induced
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Antineoplastic Combined Chemotherapy Protocols / adverse effects
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Carcinoma, Non-Small-Cell Lung / drug therapy*
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Carcinoma, Non-Small-Cell Lung / genetics
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Carcinoma, Non-Small-Cell Lung / pathology
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Disease-Free Survival
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Drug Combinations
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Drug Therapy / methods
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ErbB Receptors / genetics
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Female
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Humans
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Logistic Models
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Lung Neoplasms / drug therapy*
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Lung Neoplasms / genetics
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Lung Neoplasms / pathology
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Male
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Middle Aged
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Multivariate Analysis
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Mutation
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Nausea / chemically induced
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Neoplasm Staging
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Organoplatinum Compounds / administration & dosage
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Organoplatinum Compounds / adverse effects
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Oxonic Acid / administration & dosage
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Oxonic Acid / adverse effects
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Tegafur / administration & dosage
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Tegafur / adverse effects
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Treatment Failure
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Treatment Outcome
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Vomiting / chemically induced
Substances
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Drug Combinations
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Organoplatinum Compounds
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S 1 (combination)
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Tegafur
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Oxonic Acid
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nedaplatin
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ErbB Receptors