Abstract
A short-term open prospective study examined 62 patients at the terminal stage of chronic renal failure. The experimental group received erythropoietin in a total dose of about 40,000 U. The expression of glycoproteins IIb-IIIa, IIb, and Ib was enhanced, the content of LPO products was elevated, and SOD and catalase activities were reduced in platelets from patients with chronic renal failure. Administration of erythropoietin partially restored free radical oxidation and expression of glycoproteins IIb-IIIa, IIb, and Ib in platelets. A significant correlation was revealed between the expression of platelet receptors on the one hand, and content of LPO products and SOD and catalase activities, on the other hand.
Publication types
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Randomized Controlled Trial
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Research Support, Non-U.S. Gov't
MeSH terms
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Blood Platelets / drug effects*
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Blood Platelets / metabolism
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Catalase / blood
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Drug Administration Schedule
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Erythropoietin / therapeutic use*
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Female
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Free Radicals / antagonists & inhibitors*
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Free Radicals / metabolism
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Gene Expression / drug effects*
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Humans
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Kidney / drug effects
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Kidney / metabolism
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Kidney / pathology
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Kidney Failure, Chronic / drug therapy*
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Kidney Failure, Chronic / genetics
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Kidney Failure, Chronic / metabolism
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Kidney Failure, Chronic / pathology
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Lipid Peroxidation / drug effects
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Male
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Middle Aged
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Oxidation-Reduction
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Platelet Glycoprotein GPIIb-IIIa Complex / antagonists & inhibitors
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Platelet Glycoprotein GPIIb-IIIa Complex / genetics
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Platelet Glycoprotein GPIIb-IIIa Complex / metabolism
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Platelet Glycoprotein GPIb-IX Complex / antagonists & inhibitors
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Platelet Glycoprotein GPIb-IX Complex / genetics
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Platelet Glycoprotein GPIb-IX Complex / metabolism
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Platelet Membrane Glycoprotein IIb / genetics
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Platelet Membrane Glycoprotein IIb / metabolism
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Prospective Studies
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Superoxide Dismutase / blood
Substances
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Free Radicals
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Platelet Glycoprotein GPIIb-IIIa Complex
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Platelet Glycoprotein GPIb-IX Complex
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Platelet Membrane Glycoprotein IIb
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Erythropoietin
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Catalase
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Superoxide Dismutase