Clusterin variants are not associated with southern Chinese patients with Alzheimer's disease

Shen-Ji Lu; Hong-Lei Li; Yi-Min Sun; Zhi-Jun Liu; Ping Yang; Zhi-Ying Wu

doi:10.1016/j.neurobiolaging.2014.05.015

Clusterin variants are not associated with southern Chinese patients with Alzheimer's disease

Neurobiol Aging. 2014 Nov;35(11):2656.e9-2656.e11. doi: 10.1016/j.neurobiolaging.2014.05.015. Epub 2014 May 29.

Authors

Shen-Ji Lu¹, Hong-Lei Li¹, Yi-Min Sun¹, Zhi-Jun Liu¹, Ping Yang¹, Zhi-Ying Wu²

Affiliations

¹ Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China.
² Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Institutes of Brain Science and State Key Laboratory of Medical Neurobiology, Shanghai Medical College, Fudan University, Shanghai, China. Electronic address: zhiyingwu@fudan.edu.cn.

PMID: 24958191
DOI: 10.1016/j.neurobiolaging.2014.05.015

Abstract

Recent genome-wide association studies identified clusterin (CLU) to be associated with sporadic Alzheimer's disease. To help clarify the relevance of CLU as genetic determinant of AD, we analyzed its association in southern Chinese Han population. This study comprised 499 sporadic Alzheimer's disease patients and 592 unrelated age- and sex-matched healthy controls. Four single-nucleotide polymorphisms (rs2279590, rs9331888, rs11136000, and rs1532278) within CLU were selected for genotyping. No positive association was found between the CLU variants and AD. Our study suggests that CLU variants may not be an AD susceptibility factor in southern Chinese Han population.

Keywords: Alzheimer's disease; Association; CLU; Chinese.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Alzheimer Disease / genetics*
Asian People / genetics*
Clusterin / genetics*
Cohort Studies
Female
Genetic Association Studies*
Genetic Predisposition to Disease / genetics
Genotype
Humans
Male
Polymorphism, Single Nucleotide / genetics*

Substances

Clusterin