Abstract
In this issue of Blood, Mraz et al show that microRNA-150 (miR-150) is the most abundantly expressed miR in chronic lymphocytic leukemia (CLL) and affects the threshold for B-cell receptor (BCR) signaling by repressing expression levels of GAB1 and FOXP1. This functional link might explain the described association between expression levels of miR-150 and prognosis.
MeSH terms
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Adaptor Proteins, Signal Transducing / biosynthesis*
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Female
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Forkhead Transcription Factors / biosynthesis*
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Gene Expression Regulation, Leukemic / genetics*
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Humans
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Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
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Male
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MicroRNAs / genetics*
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Receptors, Antigen, B-Cell / metabolism*
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Repressor Proteins / biosynthesis*
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Signal Transduction*
Substances
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Adaptor Proteins, Signal Transducing
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FOXP1 protein, human
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Forkhead Transcription Factors
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GAB1 protein, human
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MIRN150 microRNA, human
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MicroRNAs
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Receptors, Antigen, B-Cell
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Repressor Proteins