miR in CLL: more than mere markers of prognosis?

Blood. 2014 Jul 3;124(1):2-4. doi: 10.1182/blood-2014-05-574152.

Abstract

In this issue of Blood, Mraz et al show that microRNA-150 (miR-150) is the most abundantly expressed miR in chronic lymphocytic leukemia (CLL) and affects the threshold for B-cell receptor (BCR) signaling by repressing expression levels of GAB1 and FOXP1. This functional link might explain the described association between expression levels of miR-150 and prognosis.

Publication types

  • Comment

MeSH terms

  • Adaptor Proteins, Signal Transducing / biosynthesis*
  • Female
  • Forkhead Transcription Factors / biosynthesis*
  • Gene Expression Regulation, Leukemic / genetics*
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / genetics*
  • Male
  • MicroRNAs / genetics*
  • Receptors, Antigen, B-Cell / metabolism*
  • Repressor Proteins / biosynthesis*
  • Signal Transduction*

Substances

  • Adaptor Proteins, Signal Transducing
  • FOXP1 protein, human
  • Forkhead Transcription Factors
  • GAB1 protein, human
  • MIRN150 microRNA, human
  • MicroRNAs
  • Receptors, Antigen, B-Cell
  • Repressor Proteins