IL-7 and TSLP receptors: twisted sisters

Blood. 2014 Jul 3;124(1):4-5. doi: 10.1182/blood-2014-05-574327.

Abstract

In this issue of Blood, Shochat et al report mutations in receptors for interleukin-7 (IL-7) and thymic stromal lymphopoietin (TSLP), resulting in a novel dimerization mechanism that drives acute lymphoblastic leukemias.

Publication types

  • Comment

MeSH terms

  • Animals
  • Female
  • Humans
  • Mutation*
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Receptors, Cytokine / genetics*
  • Receptors, Interleukin-7 / genetics*

Substances

  • CRLF2 protein, human
  • Receptors, Cytokine
  • Receptors, Interleukin-7