A MYOD1 mutation cooperates with PI3K pathway activation in ERMS

Cancer Discov. 2014 Jul;4(7):OF19. doi: 10.1158/2159-8290.CD-RW2014-109. Epub 2014 May 15.

Abstract

A recurring point mutation in MYOD1 is found in 10% of embryonal rhabdomyosarcomas (ERMS).

MeSH terms

  • Cell Differentiation
  • Humans
  • MAP Kinase Signaling System
  • MyoD Protein / genetics*
  • Phosphatidylinositol 3-Kinases / metabolism*
  • Point Mutation
  • Prognosis
  • Rhabdomyosarcoma, Embryonal / genetics*
  • Rhabdomyosarcoma, Embryonal / pathology

Substances

  • MyoD Protein
  • MyoD1 myogenic differentiation protein
  • Phosphatidylinositol 3-Kinases