Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon

Brian P McSharry; Simone K Forbes; John Z Cao; Selmir Avdic; Emily A Machala; David J Gottlieb; Allison Abendroth; Barry Slobedman

doi:10.1128/JVI.01259-14

Human cytomegalovirus upregulates expression of the lectin galectin 9 via induction of beta interferon

J Virol. 2014 Sep;88(18):10990-4. doi: 10.1128/JVI.01259-14. Epub 2014 Jul 9.

Authors

Brian P McSharry¹, Simone K Forbes², John Z Cao², Selmir Avdic¹, Emily A Machala¹, David J Gottlieb³, Allison Abendroth¹, Barry Slobedman⁴

Affiliations

¹ Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
² Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Virus Research, Westmead Millennium Institute, Sydney, NSW, Australia.
³ Westmead Institute for Cancer Research, Westmead Millennium Institute, Sydney, NSW, Australia Sydney Medical School, University of Sydney, Sydney, NSW, Australia.
⁴ Discipline of Infectious Diseases and Immunology, Sydney Medical School, University of Sydney, Sydney, NSW, Australia Centre for Virus Research, Westmead Millennium Institute, Sydney, NSW, Australia barry.slobedman@sydney.edu.au.

Abstract

Regulation of the lectin galectin 9 (Gal-9) was investigated for the first time during human cytomegalovirus (HCMV) infection. Gal-9 transcription was significantly upregulated in transplant recipients with reactivated HCMV in vivo. In vitro, Gal-9 was potently upregulated by HCMV independently of viral gene expression, with interferon beta (IFN-β) identified as the mediator of this effect. This study defines an immunoregulatory protein potently increased by HCMV infection and a novel mechanism to control Gal-9 through IFN-β induction.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cytomegalovirus / physiology*
Cytomegalovirus Infections / genetics*
Cytomegalovirus Infections / metabolism
Cytomegalovirus Infections / virology
Galectins / genetics*
Galectins / metabolism
Host-Pathogen Interactions
Humans
Interferon-beta / genetics
Interferon-beta / metabolism*
Up-Regulation*

Substances

Galectins
LGALS9 protein, human
Interferon-beta