Sequential asymptomatic enterovirus infections in a patient with major histocompatibility complex class II primary immunodeficiency

Nadia Driss; Fethi Mellouli; Ahlem Ben Yahia; Henda Touzi; Mohamed-Ridha Barbouche; Henda Triki; Mohamed Bejaoui

doi:10.1128/JCM.01122-14

Sequential asymptomatic enterovirus infections in a patient with major histocompatibility complex class II primary immunodeficiency

J Clin Microbiol. 2014 Sep;52(9):3486-9. doi: 10.1128/JCM.01122-14. Epub 2014 Jul 16.

Authors

Nadia Driss¹, Fethi Mellouli², Ahlem Ben Yahia³, Henda Touzi³, Mohamed-Ridha Barbouche⁴, Henda Triki¹, Mohamed Bejaoui²

Affiliations

¹ Laboratory of Clinical Virology, WHO Reference Laboratory on Poliomyelitis, Institut Pasteur de Tunis, Tunisia nadiadrisschaari@gmail.com henda.triki@pasteur.rns.tn.
² Pediatrics Department, Bone Marrow Transplantation Center, Tunis, Tunisia.
³ Laboratory of Clinical Virology, WHO Reference Laboratory on Poliomyelitis, Institut Pasteur de Tunis, Tunisia.
⁴ Laboratory of Immunology, Institut Pasteur de Tunis, Tunisia.

Abstract

Patients with primary immunodeficiencies are usually susceptible to enterovirus infections and have higher risks to develop severe clinical forms. We report a unique description of a boy with major histocompatibility complex class II (MHC-II) deficiency infected by 9 different enterovirus serotypes during a 2-year period, with very mild clinical symptoms, probably due to the immunoglobulin therapy he was receiving.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adolescent
Asymptomatic Diseases
Enterovirus / classification
Enterovirus / isolation & purification*
Enterovirus Infections / diagnosis*
Enterovirus Infections / immunology*
Histocompatibility Antigens Class II / genetics*
Histocompatibility Antigens Class II / immunology
Humans
Immunologic Deficiency Syndromes / complications*
Immunologic Deficiency Syndromes / diagnosis*
Male
Serogroup

Substances

Histocompatibility Antigens Class II