Abstract
Pseudo-Sezary syndrome is a benign lymphoproliferative disorder, which clinically and pathologically mimics true Sezary syndrome. In this article, a case of pseudo-Sezary syndrome and review the literature has been reported. The patient was a 51-year-old man who developed erythroderma and palmoplantar keratoderma. The patient's medication history included fosinopril and combination metoprolol/hydrochlorothiazide. Flow cytometry showed a population of 2500 "Sezary-like" CD4726 T cells per microliter in the peripheral blood. Skin biopsy showed numerous atypical lymphocytes with epidermotropism, and there was matching dominant T-cell clonality in the skin and peripheral blood. After stopping all antihypertensive medications, the eruption resolved in its entirety.
Publication types
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Case Reports
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Research Support, U.S. Gov't, Non-P.H.S.
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Review
MeSH terms
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Adrenergic beta-1 Receptor Antagonists / adverse effects
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Angiotensin-Converting Enzyme Inhibitors / adverse effects
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Antihypertensive Agents / adverse effects*
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Biomarkers / analysis
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Biopsy
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Diagnosis, Differential
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Diuretics / adverse effects
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Drug Eruptions / etiology*
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Drug Eruptions / genetics
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Drug Eruptions / immunology
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Drug Eruptions / pathology
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Flow Cytometry
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Fosinopril / adverse effects
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Genes, T-Cell Receptor
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Humans
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Hydrochlorothiazide / adverse effects
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Immunohistochemistry
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Male
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Metoprolol / adverse effects
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Middle Aged
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Predictive Value of Tests
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Prognosis
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Sezary Syndrome / diagnosis*
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Sezary Syndrome / genetics
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Sezary Syndrome / immunology
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Sezary Syndrome / pathology
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Skin / drug effects*
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Skin / immunology
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Skin / pathology
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Skin Neoplasms / diagnosis*
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Skin Neoplasms / genetics
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Skin Neoplasms / immunology
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Skin Neoplasms / pathology
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T-Lymphocytes / drug effects*
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T-Lymphocytes / immunology
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T-Lymphocytes / pathology
Substances
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Adrenergic beta-1 Receptor Antagonists
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Angiotensin-Converting Enzyme Inhibitors
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Antihypertensive Agents
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Biomarkers
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Diuretics
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Hydrochlorothiazide
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Metoprolol
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Fosinopril