UV and melanoma: the TP53 link

Cell Res. 2014 Oct;24(10):1157-8. doi: 10.1038/cr.2014.95. Epub 2014 Jul 18.

Abstract

Ultraviolet radiation (UVR) is a major risk factor for melanoma development, but it has been unclear exactly how UVR leads to melanomagenesis. In a recent publication in Nature, Viros et al. identify TP53/Trp53 as a UVR-target gene in melanoma and show that UVR-induced TP53/Trp53 mutations accelerate BRAF(V600E)-driven melanomagenesis.

Publication types

  • Comment

MeSH terms

  • Animals
  • Cell Transformation, Neoplastic / genetics*
  • Cell Transformation, Neoplastic / radiation effects*
  • Female
  • Humans
  • Melanoma / genetics*
  • Melanoma / pathology*
  • Mutagenesis / radiation effects*
  • Proto-Oncogene Proteins B-raf / genetics*
  • Tumor Suppressor Protein p53 / genetics*
  • Ultraviolet Rays / adverse effects*

Substances

  • Tumor Suppressor Protein p53
  • Proto-Oncogene Proteins B-raf