Abstract
Ultraviolet radiation (UVR) is a major risk factor for melanoma development, but it has been unclear exactly how UVR leads to melanomagenesis. In a recent publication in Nature, Viros et al. identify TP53/Trp53 as a UVR-target gene in melanoma and show that UVR-induced TP53/Trp53 mutations accelerate BRAF(V600E)-driven melanomagenesis.
MeSH terms
-
Animals
-
Cell Transformation, Neoplastic / genetics*
-
Cell Transformation, Neoplastic / radiation effects*
-
Female
-
Humans
-
Melanoma / genetics*
-
Melanoma / pathology*
-
Mutagenesis / radiation effects*
-
Proto-Oncogene Proteins B-raf / genetics*
-
Tumor Suppressor Protein p53 / genetics*
-
Ultraviolet Rays / adverse effects*
Substances
-
Tumor Suppressor Protein p53
-
Proto-Oncogene Proteins B-raf