Association of IL-12A and IL-12B polymorphisms with Alzheimer's disease susceptibility in a Han Chinese population

J Neuroimmunol. 2014 Sep 15;274(1-2):180-4. doi: 10.1016/j.jneuroim.2014.06.026. Epub 2014 Jul 6.

Abstract

As a pro-inflammatory cytokine belonging to the interleukin (IL)-1 family, IL-12 is recently found to be involved in the pathogenesis of Alzheimer's disease (AD). Here, we investigated the relations of three potentially functional single nucleotide polymorphisms (SNPs) in IL-12A (rs2243115 and rs568408) and IL-12B (rs3212227) with late-onset AD (LOAD) risk in a Northern Han Chinese cohort containing 1133 patients and 1158 healthy controls. Our findings indicated that these SNPs in IL-12A and IL-12B can individually and jointly contribute to LOAD risk in Han Chinese, implying that the genes encoding IL-12 subunits represent novel genetic risk factors for LOAD susceptibility.

Keywords: Alzheimer's disease; Association; Gene; IL-12; Polymorphism; Pro-inflammatory cytokine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / ethnology
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / immunology
  • Asian People / genetics*
  • Asian People / statistics & numerical data
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease / ethnology
  • Genetic Predisposition to Disease / genetics
  • Genotype
  • Humans
  • Interleukin-12 Subunit p35 / genetics*
  • Interleukin-12 Subunit p35 / immunology
  • Interleukin-12 Subunit p40 / genetics*
  • Interleukin-12 Subunit p40 / immunology
  • Male
  • Polymorphism, Single Nucleotide / immunology*
  • Risk Factors

Substances

  • IL12A protein, human
  • IL12B protein, human
  • Interleukin-12 Subunit p35
  • Interleukin-12 Subunit p40