Abstract
Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adolescent
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Adult
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Alleles
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Anti-Inflammatory Agents, Non-Steroidal / adverse effects
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Brazil
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Child
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Dry Eye Syndromes / ethnology
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Dry Eye Syndromes / etiology
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Dry Eye Syndromes / genetics*
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Dry Eye Syndromes / immunology
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Epithelium, Corneal / immunology
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Epithelium, Corneal / pathology
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Ethnicity
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Female
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Gene Frequency
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HLA-A2 Antigen / genetics*
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HLA-A2 Antigen / immunology
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HLA-B44 Antigen / genetics*
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HLA-B44 Antigen / immunology
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Humans
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India
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Male
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Middle Aged
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Multi-Ingredient Cold, Flu, and Allergy Medications / adverse effects
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Republic of Korea
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Retinal Pigment Epithelium / immunology
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Retinal Pigment Epithelium / pathology
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Risk Factors
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Stevens-Johnson Syndrome / ethnology
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Stevens-Johnson Syndrome / etiology
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Stevens-Johnson Syndrome / genetics*
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Stevens-Johnson Syndrome / immunology
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Trichiasis / ethnology
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Trichiasis / etiology
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Trichiasis / genetics*
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Trichiasis / immunology
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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HLA-A*02:06 antigen
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HLA-A2 Antigen
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HLA-B*44:03 antigen
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HLA-B44 Antigen
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Multi-Ingredient Cold, Flu, and Allergy Medications