Trans-ethnic study confirmed independent associations of HLA-A*02:06 and HLA-B*44:03 with cold medicine-related Stevens-Johnson syndrome with severe ocular surface complications

Sci Rep. 2014 Aug 7:4:5981. doi: 10.1038/srep05981.

Abstract

Stevens-Johnson syndrome (SJS) and its severe variant, toxic epidermal necrolysis (TEN), are acute inflammatory vesiculobullous reactions of the skin and mucous membranes. Cold medicines including non-steroidal anti-inflammatory drugs and multi-ingredient cold medications are reported to be important inciting drugs. Recently, we reported that cold medicine related SJS/TEN (CM-SJS/TEN) with severe mucosal involvement including severe ocular surface complications (SOC) is associated with HLA-A*02:06 and HLA-B*44:03 in the Japanese. In this study, to determine whether HLA-B*44:03 is a common risk factor for CM-SJS/TEN with SOC in different ethnic groups we used samples from Indian, Brazilian, and Korean patients with CM-SJS/TEN with SOC, and investigated the association between CM-SJS/TEN with SOC and HLA-B*44:03 and/or HLA-A*02:06. We found that HLA-B*44:03 was significantly associated with CM-SJS/TEN with SOC in the Indian and Brazilian but not the Korean population, and that HLA-A*02:06 might be weakly associated in the Korean- but not the Indian and Brazilian population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Alleles
  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects
  • Brazil
  • Child
  • Dry Eye Syndromes / ethnology
  • Dry Eye Syndromes / etiology
  • Dry Eye Syndromes / genetics*
  • Dry Eye Syndromes / immunology
  • Epithelium, Corneal / immunology
  • Epithelium, Corneal / pathology
  • Ethnicity
  • Female
  • Gene Frequency
  • HLA-A2 Antigen / genetics*
  • HLA-A2 Antigen / immunology
  • HLA-B44 Antigen / genetics*
  • HLA-B44 Antigen / immunology
  • Humans
  • India
  • Male
  • Middle Aged
  • Multi-Ingredient Cold, Flu, and Allergy Medications / adverse effects
  • Republic of Korea
  • Retinal Pigment Epithelium / immunology
  • Retinal Pigment Epithelium / pathology
  • Risk Factors
  • Stevens-Johnson Syndrome / ethnology
  • Stevens-Johnson Syndrome / etiology
  • Stevens-Johnson Syndrome / genetics*
  • Stevens-Johnson Syndrome / immunology
  • Trichiasis / ethnology
  • Trichiasis / etiology
  • Trichiasis / genetics*
  • Trichiasis / immunology

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • HLA-A*02:06 antigen
  • HLA-A2 Antigen
  • HLA-B*44:03 antigen
  • HLA-B44 Antigen
  • Multi-Ingredient Cold, Flu, and Allergy Medications