Abstract
MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage survival. Pigmentation itself plays an important role as the interface between genetic and environmental factors that contribute to melanoma.
Keywords:
MITF; Melanocyte; Melanoma; Pigmentation.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Animals
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Carcinogenesis
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Cell Cycle
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Cell Movement
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Cell Survival
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Cell Transformation, Neoplastic / genetics
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Cell Transformation, Neoplastic / metabolism
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Humans
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Melanins / metabolism
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Melanocytes / metabolism
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Melanocytes / pathology
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Melanoma / etiology*
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Melanoma / metabolism*
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Melanoma / pathology
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Microphthalmia-Associated Transcription Factor / genetics
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Microphthalmia-Associated Transcription Factor / metabolism*
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Neoplasm Invasiveness
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Oxidative Stress
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Pigmentation / genetics
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Pigmentation / physiology*
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Skin Neoplasms / etiology*
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Skin Neoplasms / metabolism*
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Skin Neoplasms / pathology
Substances
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Melanins
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Microphthalmia-Associated Transcription Factor