Mutational analysis of Pneumocystis jirovecii dihydropteroate synthase and dihydrofolate reductase genes in HIV-infected patients in China

J Clin Microbiol. 2014 Nov;52(11):4017-9. doi: 10.1128/JCM.01848-14. Epub 2014 Aug 13.

Abstract

We investigated Pneumocystis jirovecii dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR) genes for mutations in 25 Chinese HIV-infected patients with P. jirovecii pneumonia. We identified DHPS mutations in 3 (12%) patients and DHFR mutations in 1 (4%) patient. The prevalence of DHPS and DHFR mutations in China remains low, as it does in other developing countries.

Publication types

  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • China
  • Dihydropteroate Synthase / genetics*
  • Female
  • HIV Infections / complications*
  • Humans
  • Male
  • Middle Aged
  • Mutant Proteins / genetics
  • Mutation*
  • Pneumocystis carinii / enzymology*
  • Pneumocystis carinii / genetics
  • Prevalence
  • Tetrahydrofolate Dehydrogenase / genetics*

Substances

  • Mutant Proteins
  • Tetrahydrofolate Dehydrogenase
  • Dihydropteroate Synthase