Association of ICAM-1 K469E polymorphism with neurocysticercosis

J Neuroimmunol. 2014 Nov 15;276(1-2):166-71. doi: 10.1016/j.jneuroim.2014.07.018. Epub 2014 Aug 2.

Abstract

Neurocysticercosis (NCC), a central nervous system (CNS) disease is caused by the larval stage of Taenia solium. The disease is heterogeneous in clinical presentation; some infected individuals develop symptoms and others may remain symptom free. Impaired blood brain barrier allows recruitment of immune cells in the CNS during infection and soluble intercellular adhesion molecule-1 (sICAM-1) plays an important role in the recruitment of immune cells. We studied ICAM-1 K469E polymorphism among symptomatic and asymptomatic NCC patients. The study revealed that individuals with variant (EE) genotype were more susceptible to symptomatic NCC and also had an elevated level of sICAM-1.

Keywords: ICAM-1 polymorphism; Neurocysticercosis; Symptomatic NCC.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Case-Control Studies
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genotype
  • Glutamine / genetics*
  • Humans
  • Intercellular Adhesion Molecule-1 / genetics*
  • Lysine / genetics*
  • Male
  • Neurocysticercosis / genetics*
  • Polymorphism, Single Nucleotide / genetics*
  • Young Adult

Substances

  • Glutamine
  • Intercellular Adhesion Molecule-1
  • Lysine