Impact of VEGFA -583C > T polymorphism on serum VEGF levels and the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease

Pediatr Blood Cancer. 2014 Dec;61(12):2310-2. doi: 10.1002/pbc.25158. Epub 2014 Aug 17.

Abstract

We investigated the association of VEGFA -583C > T on VEGF serum levels and acute chest syndrome (ACS) in 351 pediatric patients with sickle cell disease (SCD), of whom 90 had ACS, and 261 were ACS-free controls. Significant differences in -583C > T minor allele and genotype frequencies were seen between ACS cases and controls, evidenced by enrichment of -583T/T genotypes in patients with ACS, which were linked with reduction in VEGF serum levels. VEGFA -583C > T and reduced VEGF serum levels may influence ACS risk in patients with SCD, which will aid in identifying patients with SCD who are at high risk of ACS.

Keywords: VEGF; acute chest syndrome; genotypes; polymorphisms; sickle cell disease.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acute Chest Syndrome / blood*
  • Acute Chest Syndrome / diagnosis
  • Acute Chest Syndrome / genetics*
  • Adolescent
  • Anemia, Sickle Cell / complications*
  • Anemia, Sickle Cell / genetics
  • Case-Control Studies
  • Child
  • Child, Preschool
  • Disease Susceptibility
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Follow-Up Studies
  • Genotype
  • Humans
  • Male
  • Polymorphism, Single Nucleotide*
  • Prognosis
  • Real-Time Polymerase Chain Reaction
  • Retrospective Studies
  • Vascular Endothelial Growth Factor A / blood*
  • Vascular Endothelial Growth Factor A / genetics*

Substances

  • VEGFA protein, human
  • Vascular Endothelial Growth Factor A