MicroRNA-29a suppresses the growth, migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen-related cell adhesion molecule 6

Hye Sook Han; Seung-Myoung Son; Jieun Yun; Yeong Nang Jo; Ok-Jun Lee

doi:10.1016/j.febslet.2014.08.023

MicroRNA-29a suppresses the growth, migration, and invasion of lung adenocarcinoma cells by targeting carcinoembryonic antigen-related cell adhesion molecule 6

FEBS Lett. 2014 Oct 16;588(20):3744-50. doi: 10.1016/j.febslet.2014.08.023. Epub 2014 Aug 27.

Authors

Hye Sook Han¹, Seung-Myoung Son², Jieun Yun³, Yeong Nang Jo³, Ok-Jun Lee⁴

Affiliations

¹ Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, South Korea.
² Department of Pathology, College of Medicine, Chungbuk National University, Cheongju, South Korea.
³ Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, South Korea.
⁴ Department of Pathology, College of Medicine, Chungbuk National University, Cheongju, South Korea. Electronic address: ok5218@hanmail.net.

PMID: 25171863
DOI: 10.1016/j.febslet.2014.08.023

Abstract

Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) is an important regulator of cell adhesion, invasion, and metastasis. The aim of this study was to evaluate the functional roles of CEACAM6 in lung adenocarcinoma and to identify miRNAs that inhibit the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. CEACAM6 expression is associated with poor prognosis of patients with lung adenocarcinoma, and CEACAM6 has important functional roles in controlling the growth, migration, and invasion of lung adenocarcinoma cells in vitro and in vivo. Furthermore, miR-29a can suppress the growth, migration, and invasion of lung adenocarcinoma cells by targeting CEACAM6. Therefore, miR-29a/CEACAM6 axis represents a potential therapeutic target for treatment of lung adenocarcinoma.

Keywords: Carcinoembryonic antigen-related cell adhesion molecule 6; Lung adenocarcinoma; MicroRNA 29a.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenocarcinoma / diagnosis
Adenocarcinoma / genetics
Adenocarcinoma / metabolism*
Animals
Antigens, CD / genetics*
Antigens, CD / metabolism
Cell Adhesion Molecules / genetics*
Cell Adhesion Molecules / metabolism
Cell Line, Tumor
Cell Movement*
Cell Proliferation*
GPI-Linked Proteins / genetics
GPI-Linked Proteins / metabolism
Humans
Lung Neoplasms / diagnosis
Lung Neoplasms / genetics
Lung Neoplasms / metabolism*
Mice
Mice, Inbred BALB C
Mice, Nude
MicroRNAs / genetics*
MicroRNAs / metabolism
Neoplasm Invasiveness
Neoplasms, Experimental / metabolism
Neoplasms, Experimental / pathology
Prognosis

Substances

Antigens, CD
CEACAM6 protein, human
Cell Adhesion Molecules
GPI-Linked Proteins
MIRN29a microRNA, human
MicroRNAs