Abstract
Mutant IDH prevents hepatocyte differentiation and promotes tumorigenesis via HNF-4α inhibition.
©2014 American Association for Cancer Research.
MeSH terms
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Animals
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Bile Duct Neoplasms / pathology*
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Cell Differentiation / genetics*
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Cholangiocarcinoma / pathology*
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Female
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Hepatocyte Nuclear Factor 4 / antagonists & inhibitors*
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Hepatocytes / pathology*
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Humans
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Isocitrate Dehydrogenase / genetics*
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Male
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Mutant Proteins / metabolism*
Substances
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Hepatocyte Nuclear Factor 4
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Mutant Proteins
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Isocitrate Dehydrogenase