HNF-4α-mediated hepatocyte differentiation is blocked by mutant IDH

Cancer Discov. 2014 Sep;4(9):OF9. doi: 10.1158/2159-8290.CD-RW2014-151. Epub 2014 Jul 17.

Abstract

Mutant IDH prevents hepatocyte differentiation and promotes tumorigenesis via HNF-4α inhibition.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bile Duct Neoplasms / pathology*
  • Cell Differentiation / genetics*
  • Cholangiocarcinoma / pathology*
  • Female
  • Hepatocyte Nuclear Factor 4 / antagonists & inhibitors*
  • Hepatocytes / pathology*
  • Humans
  • Isocitrate Dehydrogenase / genetics*
  • Male
  • Mutant Proteins / metabolism*

Substances

  • Hepatocyte Nuclear Factor 4
  • Mutant Proteins
  • Isocitrate Dehydrogenase