Abstract
Metabolic dysfunction exacerbates Alzheimer's disease (AD) incidence and progression. Here we report that activation of the AMPK pathway, a common target in the management of diabetes, results in gender-divergent cognitive effects in a murine model of the disease. Specifically, our results show that activation of AMPK increases memory dysfunction in males but is protective in females, suggesting that gender considerations may constitute an important factor in medical intervention of diabetes as well as AD.
Keywords:
AMPK; Alzheimer's disease; metformin; type 2 diabetes mellitus.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Alzheimer Disease / complications*
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Alzheimer Disease / genetics
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Amyloid beta-Protein Precursor / genetics
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Analysis of Variance
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Animals
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Blood Glucose / drug effects
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Disease Models, Animal
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Fasting
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Humans
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Hypoglycemic Agents / therapeutic use*
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Maze Learning / drug effects
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Memory Disorders / drug therapy*
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Memory Disorders / etiology*
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Memory Disorders / genetics
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Metformin / therapeutic use*
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Mice
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Mice, Inbred C57BL
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Mice, Transgenic
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Mutation / genetics
Substances
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Amyloid beta-Protein Precursor
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Blood Glucose
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Hypoglycemic Agents
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Metformin