MLL partner genes in secondary acute lymphoblastic leukemia: report of a new partner PRRC1 and review of the literature

Leuk Res. 2014 Nov;38(11):1316-9. doi: 10.1016/j.leukres.2014.08.011. Epub 2014 Aug 29.

Abstract

Secondary acute lymphoblastic leukemia (sALL) following chemotherapy and/or radiotherapy of previous malignancies represents 2-10% of all cases of ALL. A 72-year-old female patient was diagnosed with acute lymphoblastic leukemia following chemotherapy for a diffuse large B cell lymphoma. Banding cytogenetics showed a t(t(5;11)(q23-31;q23) in 20 of the 21 metaphases examined and fluorescent in situ hybridization confirmed rearrangement of MLL. Long distance inverse-polymerase chain reaction revealed an in-frame fusion between 5'MLL and 3'PRRC1. Sixty-five cases of sALL associated with 11q23/MLL rearrangement, including 47 with a t(4;11)(q21;q23), were retrieved from the literature. Drug regimen used to treat the primary neoplasm was available for 54 patients; 52 had received a topoisomerase II inhibitor, known to induce MLL rearrangement.

Keywords: Acute lymphoblastic leukemia; Fusion gene; MLL; PRRC1; Secondary leukemia.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Chromosomes, Human, Pair 11
  • Chromosomes, Human, Pair 5
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Membrane Proteins / genetics*
  • Myeloid-Lymphoid Leukemia Protein / genetics*
  • Neoplasms, Second Primary / etiology
  • Neoplasms, Second Primary / genetics*
  • Polymerase Chain Reaction
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / etiology
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / genetics*
  • Translocation, Genetic

Substances

  • KMT2A protein, human
  • Membrane Proteins
  • PRRC1 protein, human
  • Myeloid-Lymphoid Leukemia Protein
  • Histone-Lysine N-Methyltransferase