ALCAM and CD6--multiple sclerosis risk factors

J Neuroimmunol. 2014 Nov 15;276(1-2):98-103. doi: 10.1016/j.jneuroim.2014.08.621. Epub 2014 Aug 30.

Abstract

ALCAM and CD6 may play an important role in the pathogenesis of multiple sclerosis (MS), since they are involved in the transmigration of leukocytes across the blood-brain barrier. In this study, we confirmed our previous findings about the association of the ALCAM gene with risk, development and progression of MS. Additionally, we showed that in the case of the CD6 gene (encoding receptor of ALCAM) not only polymorphisms but also mRNA expression level are associated with MS. Our analysis revealed that the risk of the disease for AA individuals in rs12360861 was almost 3.0-fold lower in comparison to GG individuals (OR=0.34; CI95%=0.12; 0.81). Moreover, we observed lower expression of CD6 mRNA in patients than in healthy individuals (T(2)2,74=6.678; p=0.002).

Keywords: Gene–gene interaction; Multiple sclerosis; Polymorphism; mRNA expression.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antigens, CD / genetics*
  • Antigens, CD / metabolism
  • Antigens, Differentiation, T-Lymphocyte / genetics*
  • Antigens, Differentiation, T-Lymphocyte / metabolism
  • Cell Adhesion Molecules, Neuronal / genetics*
  • Cell Adhesion Molecules, Neuronal / metabolism
  • Disability Evaluation
  • Female
  • Fetal Proteins / genetics*
  • Fetal Proteins / metabolism
  • Genetic Association Studies
  • Genetic Predisposition to Disease / genetics*
  • HLA-DRB1 Chains / genetics
  • Humans
  • Male
  • Middle Aged
  • Multiple Sclerosis / genetics*
  • Multiple Sclerosis / metabolism
  • Polymorphism, Single Nucleotide / genetics*
  • Risk Factors
  • Severity of Illness Index
  • Young Adult

Substances

  • ALCAM protein, human
  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD6 antigen
  • Cell Adhesion Molecules, Neuronal
  • Fetal Proteins
  • HLA-DRB1 Chains