DNA methylation state of BDNF gene is not altered in prefrontal cortex and striatum of schizophrenia subjects

Psychiatry Res. 2014 Dec 30;220(3):1147-50. doi: 10.1016/j.psychres.2014.08.022. Epub 2014 Aug 28.

Abstract

In this study we assessed the BDNF promoter IV methylation state of a large genomic region surrounding promoter IV and evaluated BDNF transcript IV expression from prefrontal cortex and striatum of 15 schizophrenic and 15 control subjects. In prefrontal cortex, a single CpG site at -93, appeared to be undermethylated in patients׳group. BDNF mRNA levels in frontal cortex and striatum were variable among individuals but did not associate with disease.

Keywords: BDNF; DNA methylation; Schizophrenia.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged, 80 and over
  • Brain-Derived Neurotrophic Factor / genetics*
  • Corpus Striatum / metabolism
  • Corpus Striatum / pathology
  • DNA Methylation / genetics*
  • Female
  • Frontal Lobe / metabolism
  • Gene Expression / genetics
  • Humans
  • Male
  • Middle Aged
  • Prefrontal Cortex / metabolism*
  • Prefrontal Cortex / pathology
  • Promoter Regions, Genetic / genetics
  • RNA, Messenger / metabolism
  • Schizophrenia / genetics*
  • Schizophrenia / pathology
  • Statistics as Topic
  • Young Adult

Substances

  • Brain-Derived Neurotrophic Factor
  • RNA, Messenger
  • BDNF protein, human