Abstract
Deep-sequencing of a primary tumor and metastasis from a single patient, and functional validation in culture, reveals that TGFBR2 and FGFR2 act as drivers of gastric cancer.
Publication types
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Introductory Journal Article
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Research Support, Non-U.S. Gov't
MeSH terms
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Disease Progression
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Gene Amplification
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High-Throughput Nucleotide Sequencing / methods*
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Humans
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Neoplasm Metastasis
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Protein Serine-Threonine Kinases / genetics*
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Receptor, Fibroblast Growth Factor, Type 2 / genetics*
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Receptor, Transforming Growth Factor-beta Type II
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Receptors, Transforming Growth Factor beta / genetics*
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Sequence Analysis, DNA / methods*
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Sequence Deletion
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Stomach Neoplasms / genetics*
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Stomach Neoplasms / pathology
Substances
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Receptors, Transforming Growth Factor beta
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FGFR2 protein, human
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Receptor, Fibroblast Growth Factor, Type 2
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Protein Serine-Threonine Kinases
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Receptor, Transforming Growth Factor-beta Type II