Association of ALOX5AP rs10507391/SG13S114 A>T polymorphism with cerebral infarction in the Chinese population: a meta-analysis study

Various studies have investigated that the single nucleotide polymorphisms (SNPs) rs10507391/SG13S114 A>T polymorphism could increase the risk of cerebral infarction, however these results still remain controversial. Therefore we conducted a meta-analysis to estimate the association of the 5-lipoxygenase-activating protein gene (ALOX5AP) rs10507391/SG13S114 A > T polymorphism with the incidence of cerebral infarction in the Chinese population. Our researchers searched PubMed, Embase, Web of Science databases, China Biological Medicine Database (CBMD), Wanfang Chinese database, and the Chinese National Knowledge Infrastructure (CNKI) database. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were extracted and pooled to assess the strength of the association between the ALOX5AP rs10507391/SG13S114 A>T polymorphism and incidence of cerebral infarction. A total of 12 eligible studies including 6,844 cases and 7,850 controls based on the search criteria were involved in this meta-analysis. The distributions of genotypes in the cases and controls were all in agreement with Hardy-Weinberg equilibrium. We observed that the ALOX5AP rs10507391/SG13S114 A>T polymorphism carried with T allele contrast model, the homozygote codominant model, the heterozygote codominant model, the dominant model and the recessive model (all the models p > 0.05) had no risk of cerebral infarction when all studies were pooled into the meta-analysis. The results of the meta-analysis indicate that ALOX5AP rs10507391/SG13S114 A>T polymorphism is not associated with the risk of cerebral infarction in the Chinese population.