Population-based analysis of cholesteryl ester transfer protein identifies association between I405V and cognitive decline: the Cache County Study

Neurobiol Aging. 2015 Jan;36(1):547.e1-3. doi: 10.1016/j.neurobiolaging.2014.08.022. Epub 2014 Aug 27.

Abstract

Cholesterol has been implicated in the pathogenesis of late-onset Alzheimer's disease (LOAD) and the cholesteryl ester transfer protein (CETP) is critical to cholesterol regulation within the cell, making CETP an Alzheimer's disease candidate gene. Several studies have suggested that CETP I405V (rs5882) is associated with cognitive function and LOAD risk, but findings vary and most studies have been conducted using relatively small numbers of samples. To test whether this variant is involved in cognitive function and LOAD progression, we genotyped 4486 subjects with up to 12 years of longitudinal cognitive assessment. Analyses revealed an average 0.6-point decrease per year in the rate of cognitive decline for each additional valine (p < 0.011). We failed to detect the association between CETP I405V and LOAD status (p < 0.28). We conclude that CETP I405V is associated with preserved cognition over time but is not associated with LOAD status.

Keywords: Alzheimer's; Alzheimer's disease; CETP; Cache county; Cognitive decline; I405V.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Alzheimer Disease / genetics*
  • Alzheimer Disease / psychology*
  • Cholesterol Ester Transfer Proteins / genetics*
  • Cholesterol Ester Transfer Proteins / physiology*
  • Cognition*
  • Disease Progression
  • Female
  • Genetic Variation
  • Humans
  • Male
  • Risk
  • United States

Substances

  • CETP protein, human
  • Cholesterol Ester Transfer Proteins