Pericentrin: critical for spindle orientation

Yi Luo; Laurence Pelletier

doi:10.1016/j.cub.2014.08.062

Pericentrin: critical for spindle orientation

Curr Biol. 2014 Oct 6;24(19):R962-4. doi: 10.1016/j.cub.2014.08.062.

Authors

Yi Luo¹, Laurence Pelletier²

Affiliations

¹ Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.
² Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: pelletier@lunenfeld.ca.

PMID: 25291638
DOI: 10.1016/j.cub.2014.08.062

Abstract

Mutations in the pericentrin (PCNT) gene cause Majewski osteodysplastic primordial dwarfism type II (MOPDII). Recent work reveals that a discrete set of centrosome proteins require PCNT for their robust localization to mitotic spindle poles. Critically, this complex is crucial for mitotic spindle orientation and involved in the pathogenesis of MOPDII.

Publication types

Comment

MeSH terms

Animals
Antigens / genetics*
Dwarfism / genetics*
Fetal Growth Retardation / genetics*
Humans
Microcephaly / genetics*
Microtubules / genetics*
Mitosis*
Osteochondrodysplasias / genetics*
Spindle Apparatus / genetics*

Substances

Antigens
pericentrin

Supplementary concepts

Microcephalic Osteodysplastic Primordial Dwarfism, Type II