The double life of p85

Carlotta Costa; Jeffrey A Engelman

doi:10.1016/j.ccell.2014.09.011

The double life of p85

Cancer Cell. 2014 Oct 13;26(4):445-7. doi: 10.1016/j.ccell.2014.09.011.

Authors

Carlotta Costa¹, Jeffrey A Engelman²

Affiliations

¹ Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA.
² Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, MA 02129, USA. Electronic address: jengelman@mgh.harvard.edu.

PMID: 25314071
DOI: 10.1016/j.ccell.2014.09.011

Abstract

A growing number of mutations in PIK3R1, the gene that encodes for the p85α regulatory subunit of PI3K, have been recently identified. In this issue of Cancer Cell, Cheung and colleagues describe two neomorphic PIK3R1 mutants prevalent in endometrial and colon cancer that induce transformation via activation of PI3K-independent pathways.

MeSH terms

Class Ia Phosphatidylinositol 3-Kinase
Colonic Neoplasms / genetics
Endometrial Neoplasms / genetics
Female
Humans
Mutation*
Phosphatidylinositol 3-Kinases / genetics
Phosphatidylinositol 3-Kinases / physiology*

Substances

PIK3R1 protein, human
Class Ia Phosphatidylinositol 3-Kinase