Abstract
Humans deficient in the adaptor MyD88 or the kinase IRAK4 suffer from primary immunodeficiency. Blood cells from these patients show defective induction of specific subsets of genes after exposure to microbial stimuli in vitro.
MeSH terms
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Female
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Humans
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Immunologic Deficiency Syndromes / genetics*
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Immunologic Deficiency Syndromes / immunology*
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Interleukin-1 Receptor-Associated Kinases / genetics*
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Interleukin-1 Receptor-Associated Kinases / immunology
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Male
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Mutation*
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Myeloid Differentiation Factor 88 / genetics*
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Primary Immunodeficiency Diseases
Substances
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MYD88 protein, human
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Myeloid Differentiation Factor 88
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IRAK4 protein, human
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Interleukin-1 Receptor-Associated Kinases
Supplementary concepts
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IRAK4 Deficiency
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MYD88 Deficiency