Drug combos validated in BRAF-mutant melanoma

Cancer Discov. 2014 Dec;4(12):1361-2. doi: 10.1158/2159-8290.CD-NB2014-155. Epub 2014 Oct 15.

Abstract

Studies presented or published during the European Society for Medical Oncology conference demonstrate that combining BRAF and MEK inhibitors improves progression-free and overall survival--and lowers the risk of resistance and toxicities--in patients with metastatic melanoma with BRAF V600E or V600K mutations.

Publication types

  • News

MeSH terms

  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
  • Humans
  • Melanoma / drug therapy*
  • Melanoma / genetics*
  • Mutation*
  • Protein Kinase Inhibitors / administration & dosage
  • Proto-Oncogene Proteins B-raf / genetics*
  • Treatment Outcome

Substances

  • Protein Kinase Inhibitors
  • Proto-Oncogene Proteins B-raf