Abstract
Lycorine, a natural alkaloid, has been widely reported to possess potential efficacy against cancer. However, the anti-multiple myeloma mechanism of lycorine is not fully understood. In this study, the results demonstrated that lycorine is effective against multiple myeloma cell line ARH-77 via inducing programmed necrosis. The mechanisms of lycorine on the multiple myeloma cell line ARH-77 are associated with G1 phase cell cycle arrest, mitochondrial dysfunction, reactive oxygen species (ROS) generation, ATP depletion, and DNA damage. Our results elucidate the new mechanism of lycorine against multiple myeloma.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amaryllidaceae Alkaloids / administration & dosage*
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Amaryllidaceae Alkaloids / chemistry
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Apoptosis / drug effects*
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Caspases / biosynthesis
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Cell Line, Tumor
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DNA Damage / drug effects*
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Humans
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Mitochondria / drug effects
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Mitochondria / genetics
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Multiple Myeloma / drug therapy*
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Multiple Myeloma / genetics
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Multiple Myeloma / pathology
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Necrosis / chemically induced
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Necrosis / pathology
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Phenanthridines / administration & dosage*
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Phenanthridines / chemistry
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Proto-Oncogene Proteins c-bcl-2 / biosynthesis
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Reactive Oxygen Species / metabolism
Substances
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Amaryllidaceae Alkaloids
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Phenanthridines
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Proto-Oncogene Proteins c-bcl-2
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Reactive Oxygen Species
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Caspases
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lycorine