Arginine vasopressin 1a receptor RS3 promoter microsatellites in schizophrenia: a study of the effect of the "risk" allele on clinical symptoms and facial affect recognition

Vera Golimbet; Margarita Alfimova; Lilia Abramova; Vasily Kaleda; Inga Gritsenko

doi:10.1016/j.psychres.2014.11.043

Arginine vasopressin 1a receptor RS3 promoter microsatellites in schizophrenia: a study of the effect of the "risk" allele on clinical symptoms and facial affect recognition

Psychiatry Res. 2015 Feb 28;225(3):739-40. doi: 10.1016/j.psychres.2014.11.043. Epub 2014 Dec 3.

Authors

Vera Golimbet¹, Margarita Alfimova², Lilia Abramova², Vasily Kaleda², Inga Gritsenko³

Affiliations

¹ Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia. Electronic address: golimbet@mail.ru.
² Mental Health Research Center, Russian Academy of Medical Sciences, Kashirskoe sh. 34, Moscow 115522, Russia.
³ Department of Psychology, The Hebrew University of Jerusalem, Herzog Memorial Hospital, Givat Shaul, P.O. Box 3900, Jerusalem 91035, Israel.

PMID: 25529259
DOI: 10.1016/j.psychres.2014.11.043

Abstract

We studied AVPR1A RS3 polymorphism in schizophrenic patients and controls. AVPR1A RS3 was not associated with schizophrenia. The allele 327bp implicated in autism and social behavior was associated with negative symptoms and tended to be linked to patient facial affect recognition suggesting its impact on schizophrenia social phenotypes.

Keywords: AVPR1A; PANSS; Psychosis.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Alleles
Autistic Disorder / genetics*
Autistic Disorder / physiopathology
Emotions / physiology*
Facial Expression*
Female
Humans
Male
Microsatellite Repeats
Middle Aged
Polymorphism, Genetic
Promoter Regions, Genetic
Receptors, Vasopressin / genetics*
Risk
Schizophrenia / genetics*
Schizophrenia / physiopathology
Social Behavior*
Social Perception*

Substances

AVPR1A protein, human
Receptors, Vasopressin