Lack of association between genetic polymorphisms in three folate-related enzyme genes and male infertility in the Chinese population

J Assist Reprod Genet. 2015 Mar;32(3):369-74. doi: 10.1007/s10815-014-0423-9. Epub 2015 Jan 13.

Abstract

Purpose: This study explored the possible association of four single nucleotide polymorphisms (SNPs) of the three folate-related enzyme genes: MTHFR C677T and A1298C, MTR A2756G and MTRR A66G, with male infertility in the Chinese population.

Methods: The polymorphic distributions of the four SNPs (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) were investigated by the method of SNaPshot in a Chinese cohort including 296 idiopathic infertile males with azoospermia or oligozoospermia and 204 fertile males.

Results: We found no evidence for an association between any of these variants (MTHFR C677T and A1298C, MTR A2756G and MTRR A66G) and male infertility.

Conclusions: There is no evidence for an association between male infertility and polymorphism of the three folate-related enzyme genes in the Chinese population.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase / genetics*
  • Azoospermia / genetics
  • Azoospermia / pathology
  • China
  • Ferredoxin-NADP Reductase / genetics*
  • Folic Acid / genetics
  • Genetic Association Studies
  • Genetic Predisposition to Disease
  • Genotype
  • Humans
  • Infertility, Male / genetics*
  • Infertility, Male / pathology
  • Male
  • Methylenetetrahydrofolate Reductase (NADPH2) / genetics*
  • Polymorphism, Single Nucleotide
  • Risk Factors

Substances

  • Folic Acid
  • methionine synthase reductase
  • Ferredoxin-NADP Reductase
  • MTHFR protein, human
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
  • MTR protein, human